Phospholipase Cγ2 Mediates RANKL-stimulated Lymph Node Organogenesis and Osteoclastogenesis

Phospholipase Cγ2 (PLCγ2) is an important signaling effector of multiple receptors in the immune system. Here we show that PLCγ2-deficient mice displayed impaired lymph node organogenesis but normal splenic structure and Peyer's patches. Receptor activator of NF-κB ligand (RANKL) is a tumor nec...

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Hauptverfasser: Chen, Yabing, Wang, Xiaohong, Di, Lie, Fu, Guoping, Chen, Yuhong, Bai, Li, Liu, Jianzhong, Feng, Xu, McDonald, Jay M., Michalek, Sue, He, Yinghong, Yu, Mei, Fu, Yang-Xin, Wen, Renren, Wu, Hui, Wang, Demin
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2008
Schlagworte:
Mechanisms of Signal Transduction
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2570883/
https://ncbi.nlm.nih.gov/pubmed/18728019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M802493200
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