Integrin-associated Lyn Kinase Promotes Cell Survival by Suppressing Acid Sphingomyelinase Activity

Integrins govern cellular adhesion and transmit signals leading to activation of intracellular signaling pathways aimed to prevent apoptosis. Herein we report that attachment of oligodendrocytes (OLs) to fibronectin via α(v)β(3) integrin receptors rendered the cells more resistant to apoptosis than...

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Hlavní autoři: Chudakova, Daria A., Zeidan, Youssef H., Wheeler, Brian W., Yu, Jin, Novgorodov, Sergei A., Kindy, Mark S., Hannun, Yusuf A., Gudz, Tatyana I.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2008
Témata:
Lipids and Lipoproteins: Metabolism, Regulation, and Signaling
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2570874/
https://ncbi.nlm.nih.gov/pubmed/18682390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M803301200
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