Integrin-associated Lyn Kinase Promotes Cell Survival by Suppressing Acid Sphingomyelinase Activity

Integrins govern cellular adhesion and transmit signals leading to activation of intracellular signaling pathways aimed to prevent apoptosis. Herein we report that attachment of oligodendrocytes (OLs) to fibronectin via α(v)β(3) integrin receptors rendered the cells more resistant to apoptosis than...

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Hauptverfasser: Chudakova, Daria A., Zeidan, Youssef H., Wheeler, Brian W., Yu, Jin, Novgorodov, Sergei A., Kindy, Mark S., Hannun, Yusuf A., Gudz, Tatyana I.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2008
Schlagworte:
Lipids and Lipoproteins: Metabolism, Regulation, and Signaling
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2570874/
https://ncbi.nlm.nih.gov/pubmed/18682390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M803301200
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