Integrin-associated Lyn Kinase Promotes Cell Survival by Suppressing Acid Sphingomyelinase Activity

Integrins govern cellular adhesion and transmit signals leading to activation of intracellular signaling pathways aimed to prevent apoptosis. Herein we report that attachment of oligodendrocytes (OLs) to fibronectin via α(v)β(3) integrin receptors rendered the cells more resistant to apoptosis than...

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Библиографические подробности
Главные авторы: Chudakova, Daria A., Zeidan, Youssef H., Wheeler, Brian W., Yu, Jin, Novgorodov, Sergei A., Kindy, Mark S., Hannun, Yusuf A., Gudz, Tatyana I.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2008
Предметы:
Lipids and Lipoproteins: Metabolism, Regulation, and Signaling
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2570874/
https://ncbi.nlm.nih.gov/pubmed/18682390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M803301200
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