Ceramide Generated by Sphingomyelin Hydrolysis and the Salvage Pathway Is Involved in Hypoxia/Reoxygenation-induced Bax Redistribution to Mitochondria in NT-2 Cells

Ceramide functions as an important second messenger in apoptosis signaling pathways. In this report, we show that treatment of NT-2 neuronal precursor cells with hypoxia/reoxygenation (H/R) resulted in ceramide up-regulation. This elevation in ceramide was primarily due to the actions of acid sphing...

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Detalhes bibliográficos
Main Authors: Jin, Junfei, Hou, Qi, Mullen, Thomas D., Zeidan, Youssef H., Bielawski, Jacek, Kraveka, Jacqueline M., Bielawska, Alicja, Obeid, Lina M., Hannun, Yusuf A., Hsu, Yi-Te
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Lipids and Lipoproteins: Metabolism, Regulation, and Signaling
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2546549/
https://ncbi.nlm.nih.gov/pubmed/18676372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M801597200
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