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Promotion of Reprogramming to Ground State Pluripotency by Signal Inhibition
Induced pluripotent stem (iPS) cells are generated from somatic cells by genetic manipulation. Reprogramming entails multiple transgene integrations and occurs apparently stochastically in rare cells over many days. Tissue stem cells may be subject to less-stringent epigenetic restrictions than othe...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Public Library of Science
2008
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2570424/ https://ncbi.nlm.nih.gov/pubmed/18942890 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.0060253 |
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