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Nanog Overcomes Reprogramming Barriers and Induces Pluripotency in Minimal Conditions
Induced pluripotency requires the expression of defined factors and culture conditions that support the self-renewal of embryonic stem (ES) cells [1]. Small molecule inhibition of MAP kinase (MEK) and glycogen synthase kinase 3 (GSK3) with LIF (2i/LIF) provides an optimal culture environment for mou...
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| Main Authors: | , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Cell Press
2011
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3025321/ https://ncbi.nlm.nih.gov/pubmed/21194951 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2010.11.074 |
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