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Nanog Is the Gateway to the Pluripotent Ground State

Pluripotency is generated naturally during mammalian development through formation of the epiblast, founder tissue of the embryo proper. Pluripotency can be recreated by somatic cell reprogramming. Here we present evidence that the homeodomain protein Nanog mediates acquisition of both embryonic and...

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Detalhes bibliográficos
Main Authors: Silva, Jose, Nichols, Jennifer, Theunissen, Thorold W., Guo, Ge, van Oosten, Anouk L., Barrandon, Ornella, Wray, Jason, Yamanaka, Shinya, Chambers, Ian, Smith, Austin
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3437554/
https://ncbi.nlm.nih.gov/pubmed/19703398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2009.07.039
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