Nanog Is the Gateway to the Pluripotent Ground State

Pluripotency is generated naturally during mammalian development through formation of the epiblast, founder tissue of the embryo proper. Pluripotency can be recreated by somatic cell reprogramming. Here we present evidence that the homeodomain protein Nanog mediates acquisition of both embryonic and...

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Autori principali: Silva, Jose, Nichols, Jennifer, Theunissen, Thorold W., Guo, Ge, van Oosten, Anouk L., Barrandon, Ornella, Wray, Jason, Yamanaka, Shinya, Chambers, Ian, Smith, Austin
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cell Press 2009
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3437554/
https://ncbi.nlm.nih.gov/pubmed/19703398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2009.07.039
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