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Stat3 Activation Is Limiting for Reprogramming to Ground State Pluripotency
The cytokine leukemia inhibitory factor (Lif) sustains self-renewal of mouse embryonic and induced pluripotent stem cells by activating Jak kinase and the transcription factor Stat3. Here we investigate whether Jak/Stat3 may also contribute to induction of pluripotency. EpiSCs derived from postimpla...
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| Main Authors: | , , , , , |
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| Formáid: | Artigo |
| Teanga: | Inglês |
| Foilsithe: |
Cell Press
2010
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| Ábhair: | |
| Rochtain Ar Líne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3459098/ https://ncbi.nlm.nih.gov/pubmed/20804969 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2010.06.022 |
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