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JAK/STAT3 signalling is sufficient and dominant over antagonistic cues for the establishment of naive pluripotency

Induced pluripotency depends on cooperativity between expression of defined factors and the culture environment. The latter also determines the pluripotent cell state, that is, naïve or primed. LIF-JAK/sTAT3 signalling was recently shown to be a limiting factor for reprogramming to naïve pluripotenc...

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Detalhes bibliográficos
Main Authors: van oosten, Anouk L., Costa, Yael, Smith, Austin, Silva, José C.R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3567838/
https://ncbi.nlm.nih.gov/pubmed/22569365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms1822
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