The Transcriptional and Epigenomic Foundations of Ground State Pluripotency

Mouse embryonic stem (ES) cells grown in serum exhibit greater heterogeneity in morphology and expression of pluripotency factors than ES cells cultured in defined medium with inhibitors of two kinases (Mek and GSK3), a condition known as “2i” postulated to establish a naive ground state. We show th...

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Detalhes bibliográficos
Main Authors: Marks, Hendrik, Kalkan, Tüzer, Menafra, Roberta, Denissov, Sergey, Jones, Kenneth, Hofemeister, Helmut, Nichols, Jennifer, Kranz, Andrea, Francis Stewart, A., Smith, Austin, Stunnenberg, Hendrik G.
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3398752/
https://ncbi.nlm.nih.gov/pubmed/22541430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2012.03.026
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