The Transcriptional and Epigenomic Foundations of Ground State Pluripotency

Mouse embryonic stem (ES) cells grown in serum exhibit greater heterogeneity in morphology and expression of pluripotency factors than ES cells cultured in defined medium with inhibitors of two kinases (Mek and GSK3), a condition known as “2i” postulated to establish a naive ground state. We show th...

Full description

Saved in:
Bibliographic Details
Main Authors: Marks, Hendrik, Kalkan, Tüzer, Menafra, Roberta, Denissov, Sergey, Jones, Kenneth, Hofemeister, Helmut, Nichols, Jennifer, Kranz, Andrea, Francis Stewart, A., Smith, Austin, Stunnenberg, Hendrik G.
Format: Artigo
Language:Inglês
Published: Cell Press 2012
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3398752/
https://ncbi.nlm.nih.gov/pubmed/22541430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2012.03.026
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items