DNA helicases Sgs1 and BLM promote DNA double-strand break resection

A key cellular response to DNA double-strand breaks (DSBs) is 5′-to-3′ DSB resection by nucleases to generate regions of ssDNA that then trigger cell cycle checkpoint signaling and DSB repair by homologous recombination (HR). Here, we reveal that in the absence of exonuclease Exo1 activity, deletion...

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Bibliografiske detaljer
Main Authors: Gravel, Serge, Chapman, J. Ross, Magill, Christine, Jackson, Stephen P.
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2008
Fag:
Research Communication
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2569880/
https://ncbi.nlm.nih.gov/pubmed/18923075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.503108
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