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BLM helicase regulates DNA repair by counteracting RAD51 loading at DNA double-strand break sites

The BLM gene product, BLM, is a RECQ helicase that is involved in DNA replication and repair of DNA double-strand breaks by the homologous recombination (HR) pathway. During HR, BLM has both pro- and anti-recombinogenic activities, either of which may contribute to maintenance of genomic integrity....

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Détails bibliographiques
Publié dans:J Cell Biol
Auteurs principaux: Patel, Dharm S., Misenko, Sarah M., Her, Joonyoung, Bunting, Samuel F.
Format: Artigo
Langue:Inglês
Publié: The Rockefeller University Press 2017
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5674892/
https://ncbi.nlm.nih.gov/pubmed/28912125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201703144
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