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Total Synthesis and Evaluation of Cytostatin, its C10–C11 Diastereomers, and Additional Key Analogues: Impact on PP2A Inhibition

The total synthesis of cytostatin, an antitumor agent belonging to the fostriecin family of natural products is described in full detail. The convergent approach relied on a key epoxide opening reaction to join the two stereotriad units and a single-step late stage, stereoselective installation of t...

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Bibliografiske detaljer
Main Authors: Lawhorn, Brian G., Boga, Sobhana B., Wolkenberg, Scott E., Colby, David A., Gauss, Carla-Maria, Swingle, Mark R., Amable, Lauren, Honkanen, Richard E., Boger, Dale L.
Format: Artigo
Sprog:Inglês
Udgivet: 2006
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2566737/
https://ncbi.nlm.nih.gov/pubmed/17177422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja066477d
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