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Evaluation of Chlorofusin, its Seven Chromophore Diastereomers, and Key Analogues

Chlorofusin, its seven chromophore diastereomers, and key analogues were comparatively examined for inhibition of MDM2–p53 binding revealing that the chromophore, but not simple replacements, contributes significantly to the natural products properties, and that this contribution is independent of i...

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Detalhes bibliográficos
Main Authors: Clark, Ryan C., Lee, Sang Yeul, Hwang, Inkyu, Searcey, Mark, Boger, Dale L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2697908/
https://ncbi.nlm.nih.gov/pubmed/20161293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tetlet.2009.01.081
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