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Total Synthesis of Chlorofusin, its Seven Chromophore Diastereomers, and Key Partial Structures
Chlorofusin is a recently isolated, naturally occurring inhibitor of p53−MDM2 complex formation whose structure is composed of a densely functionalized azaphilone-derived chromophore linked through the terminal amine of ornithine to a nine residue cyclic peptide. Herein we report the full details of...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2587114/ https://ncbi.nlm.nih.gov/pubmed/18712872 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja8012819 |
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