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Total Synthesis of Chlorofusin, its Seven Chromophore Diastereomers, and Key Partial Structures

Chlorofusin is a recently isolated, naturally occurring inhibitor of p53−MDM2 complex formation whose structure is composed of a densely functionalized azaphilone-derived chromophore linked through the terminal amine of ornithine to a nine residue cyclic peptide. Herein we report the full details of...

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Bibliografiske detaljer
Main Authors: Clark, Ryan C., Lee, Sang Yeul, Boger, Dale L.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2587114/
https://ncbi.nlm.nih.gov/pubmed/18712872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja8012819
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