Structure-Activity Relationship Studies of Fostriecin, Cytostatin, and Key Analogs, with PP1, PP2A, PP5, and (β12–β13)-Chimeras (PP1/PP2A and PP5/PP2A), Provide Further Insight into the Inhibitory Actions of Fostriecin Family Inhibitors

Fostriecin and cytostatin are structurally related natural inhibitors of serine/threonine phosphatases, with promising antitumor activity. The total synthesis of these antitumor agents has enabled the production of structural analogs, which are useful to explore the biological significance of featur...

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Hlavní autoři: Swingle, Mark R., Amable, Lauren, Lawhorn, Brian G., Buck, Suzanne B., Burke, Christopher P., Ratti, Pukar, Fischer, Kimberly L., Boger, Dale L., Honkanen, Richard E.
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Pharmacology and Experimental Therapeutics 2009
Témata:
Chemotherapy, Antibiotics, and Gene Therapy
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2766224/
https://ncbi.nlm.nih.gov/pubmed/19592665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.109.155630
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