Development and Validation of a Robust and Sensitive Assay for the Discovery of Selective Inhibitors for Serine/Threonine Protein Phosphatases PP1α (PPP1C) and PP5 (PPP5C)

Protein phosphatase types 1 α (PP1α/PPP1C) and 5 (PP5/PPP5C) are members of the PPP family of serine/threonine protein phosphatases. PP1 and PP5 share a common catalytic mechanism, and several natural compounds, including okadaic acid, microcystin, and cantharidin, act as strong inhibitors of both e...

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Detalhes bibliográficos
Publicado no:Assay Drug Dev Technol
Main Authors: Swingle, Mark R., Honkanen, Richard E.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2014
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4229695/
https://ncbi.nlm.nih.gov/pubmed/25383722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/adt.2014.603
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