Scrapie-Induced Defects in Learning and Memory of Transgenic Mice Expressing Anchorless Prion Protein Are Associated with Alterations in the Gamma Aminobutyric Acid-Ergic Pathway

After infection with RML murine scrapie agent, transgenic (tg) mice expressing prion protein (PrP) without its glycophosphatidylinositol (GPI) membrane anchor (GPI(−/−) PrP tg mice) continue to make abundant amounts of the abnormally folded disease-associated PrPres but have a normal life span. In c...

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Detalhes bibliográficos
Main Authors: Trifilo, Matthew J., Sanchez-Alavez, Manuel, Solforosi, Laura, Bernard-Trifilo, Joie, Kunz, Stefan, McGavern, Dorian, Oldstone, Michael B. A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2566293/
https://ncbi.nlm.nih.gov/pubmed/18667494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00486-08
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