NPC2 facilitates bidirectional transfer of cholesterol between NPC1 and lipid bilayers, a step in cholesterol egress from lysosomes

Egress of lipoprotein-derived cholesterol from lysosomes requires two lysosomal proteins, polytopic membrane-bound Niemann–Pick C1 (NPC1) and soluble Niemann–Pick C2 (NPC2). The reason for this dual requirement is unknown. Previously, we showed that the soluble luminal N-terminal domain (NTD) of NPC...

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Détails bibliographiques
Auteurs principaux: Infante, Rodney E., Wang, Michael L., Radhakrishnan, Arun, Kwon, Hyock Joo, Brown, Michael S., Goldstein, Joseph L.
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2008
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2563079/
https://ncbi.nlm.nih.gov/pubmed/18772377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0807328105
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