ロード中...

Structure of N-terminal Domain of NPC1 Reveals Distinct Subdomains for Binding and Transfer of Cholesterol

LDL delivers cholesterol to lysosomes by receptor-mediated endocytosis. Exit of cholesterol from lysosomes requires two proteins, membrane-bound Niemann-Pick C1 (NPC1) and soluble NPC2. NPC2 binds cholesterol with its isooctyl side chain buried and its 3ß-hydroxyl exposed. Here, we describe high-res...

詳細記述

保存先:
書誌詳細
主要な著者: Kwon, Hyock Joo, Abi-Mosleh, Lina, Wang, Michael L., Deisenhofer, Johann, Goldstein, Joseph L., Brown, Michael S., Infante, Rodney E.
フォーマット: Artigo
言語:Inglês
出版事項: 2009
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2739658/
https://ncbi.nlm.nih.gov/pubmed/19563754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2009.03.049
タグ: タグ追加
タグなし, このレコードへの初めてのタグを付けませんか!