Structure of N-terminal Domain of NPC1 Reveals Distinct Subdomains for Binding and Transfer of Cholesterol

LDL delivers cholesterol to lysosomes by receptor-mediated endocytosis. Exit of cholesterol from lysosomes requires two proteins, membrane-bound Niemann-Pick C1 (NPC1) and soluble NPC2. NPC2 binds cholesterol with its isooctyl side chain buried and its 3ß-hydroxyl exposed. Here, we describe high-res...

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Hlavní autoři: Kwon, Hyock Joo, Abi-Mosleh, Lina, Wang, Michael L., Deisenhofer, Johann, Goldstein, Joseph L., Brown, Michael S., Infante, Rodney E.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2739658/
https://ncbi.nlm.nih.gov/pubmed/19563754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2009.03.049
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