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Cyclodextrin overcomes deficient lysosome-to-endoplasmic reticulum transport of cholesterol in Niemann-Pick type C cells

A handoff model has been proposed to explain the egress from lysosomes of cholesterol derived from receptor-mediated endocytosis of LDL. Cholesterol is first bound by soluble Niemann-Pick C2 (NPC2) protein, which hands off the cholesterol to the N-terminal domain of membrane-bound NPC1. Cells lackin...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Abi-Mosleh, Lina, Infante, Rodney E., Radhakrishnan, Arun, Goldstein, Joseph L., Brown, Michael S.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2009
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2780767/
https://ncbi.nlm.nih.gov/pubmed/19884502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0910916106
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