Triazoles inhibit cholesterol export from lysosomes by binding to NPC1

Niemann–Pick C1 (NPC1), a membrane protein of lysosomes, is required for the export of cholesterol derived from receptor-mediated endocytosis of LDL. Lysosomal cholesterol export is reportedly inhibited by itraconazole, a triazole that is used as an antifungal drug [Xu et al. (2010) Proc Natl Acad S...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Trinh, Michael N., Lu, Feiran, Li, Xiaochun, Das, Akash, Liang, Qiren, De Brabander, Jef K., Brown, Michael S., Goldstein, Joseph L.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2017
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5224357/
https://ncbi.nlm.nih.gov/pubmed/27994139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1619571114
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