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NPC intracellular cholesterol transporter 1 (NPC1)-mediated cholesterol export from lysosomes

Low-density lipoprotein particles are taken up by cells and delivered to the lysosome where their cholesterol esters are cleaved off by acid lipase. The released, free cholesterol is then exported from lysosomes for cellular needs or storage. This article summarizes recent advances in our understand...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Autor principal: Pfeffer, Suzanne R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6364775/
https://ncbi.nlm.nih.gov/pubmed/30710017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.TM118.004165
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