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A High-Throughput, Homogeneous, Bioluminescent Assay for Pseudomonas aeruginosa Gyrase Inhibitors and Other DNA Damaging Agents

A homogeneous, sensitive, cellular bioluminescent high throughput screen was developed for inhibitors of gyrase and other DNA damaging agents in Pseudomonas aeruginosa. The screen is based on a Photorhabdus luminescens luciferase operon transcriptional fusion to a promoter that responds to DNA damag...

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Autors principals: Moir, Donald T., Di, Ming, Opperman, Timothy, Schweizer, Herbert P., Bowlin, Terry L.
Format: Artigo
Idioma:Inglês
Publicat: 2007
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2561246/
https://ncbi.nlm.nih.gov/pubmed/17644773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1087057107304729
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