Homogeneous Assay for Target Engagement Utilizing Bioluminescent Thermal Shift

[Image: see text] Protein thermal shift assays (TSAs) provide a means for characterizing target engagement through ligand-induced thermal stabilization. Although these assays are widely utilized for screening libraries and validating hits in drug discovery programs, they can impose encumbering opera...

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Pubblicato in:ACS Med Chem Lett
Autori principali: Dart, Melanie L., Machleidt, Thomas, Jost, Emily, Schwinn, Marie K., Robers, Matthew B., Shi, Ce, Kirkland, Thomas A., Killoran, Michael P., Wilkinson, Jennifer M., Hartnett, James R., Zimmerman, Kristopher, Wood, Keith V.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2018
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6004564/
https://ncbi.nlm.nih.gov/pubmed/29937980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.8b00081
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