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Homogeneous Assay for Target Engagement Utilizing Bioluminescent Thermal Shift
[Image: see text] Protein thermal shift assays (TSAs) provide a means for characterizing target engagement through ligand-induced thermal stabilization. Although these assays are widely utilized for screening libraries and validating hits in drug discovery programs, they can impose encumbering opera...
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| Udgivet i: | ACS Med Chem Lett |
|---|---|
| Main Authors: | , , , , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Chemical
Society
2018
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| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6004564/ https://ncbi.nlm.nih.gov/pubmed/29937980 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.8b00081 |
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