Homogeneous Assay for Target Engagement Utilizing Bioluminescent Thermal Shift

[Image: see text] Protein thermal shift assays (TSAs) provide a means for characterizing target engagement through ligand-induced thermal stabilization. Although these assays are widely utilized for screening libraries and validating hits in drug discovery programs, they can impose encumbering opera...

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Udgivet i:ACS Med Chem Lett
Main Authors: Dart, Melanie L., Machleidt, Thomas, Jost, Emily, Schwinn, Marie K., Robers, Matthew B., Shi, Ce, Kirkland, Thomas A., Killoran, Michael P., Wilkinson, Jennifer M., Hartnett, James R., Zimmerman, Kristopher, Wood, Keith V.
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2018
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6004564/
https://ncbi.nlm.nih.gov/pubmed/29937980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.8b00081
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