Homogeneous Assay for Target Engagement Utilizing Bioluminescent Thermal Shift

[Image: see text] Protein thermal shift assays (TSAs) provide a means for characterizing target engagement through ligand-induced thermal stabilization. Although these assays are widely utilized for screening libraries and validating hits in drug discovery programs, they can impose encumbering opera...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:ACS Med Chem Lett
Prif Awduron: Dart, Melanie L., Machleidt, Thomas, Jost, Emily, Schwinn, Marie K., Robers, Matthew B., Shi, Ce, Kirkland, Thomas A., Killoran, Michael P., Wilkinson, Jennifer M., Hartnett, James R., Zimmerman, Kristopher, Wood, Keith V.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Chemical Society 2018
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6004564/
https://ncbi.nlm.nih.gov/pubmed/29937980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.8b00081
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg