Discovery of Bacterial Fatty Acid Synthase Type II Inhibitors Using a Novel Cellular Bioluminescent Reporter Assay

Novel, cellular, gain-of-signal, bioluminescent reporter assays for fatty acid synthesis type II (FASII) inhibitors were constructed in an efflux-deficient strain of Pseudomonas aeruginosa and based on the discovery that FASII genes in P. aeruginosa are coordinately upregulated in response to pathwa...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Wallace, Joselynn, Bowlin, Nicholas O., Mills, Debra M., Saenkham, Panatda, Kwasny, Steven M., Opperman, Timothy J., Williams, John D., Rock, Charles O., Bowlin, Terry L., Moir, Donald T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
Assuntos:
Experimental Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4538483/
https://ncbi.nlm.nih.gov/pubmed/26169404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00686-15
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