Recent advances toward a molecular mechanism of efflux pump inhibition

por Opperman, Timothy J., Nguyen, Son T.
Publicado en Front Microbiol (2015)

Optimization of a novel series of pyranopyridine RND efflux pump inhibitors

por Aron, Zachary, Opperman, Timothy J.
Publicado en Curr Opin Microbiol (2016)

The hydrophobic trap—the Achilles heel of RND efflux pumps

por Aron, Zachary, Opperman, Timothy J.
Publicado en Res Microbiol (2017)

Static biofilm cultures of Gram-positive pathogens grown in a microtiter format used for anti-biofilm drug discovery

por Kwasny, Steven M., Opperman, Timothy J.
Publicado 2010

The Escherichia coli SOS mutagenesis proteins UmuD and UmuD′ interact physically with the replicative DNA polymerase

por Sutton, Mark D., Opperman, Timothy, Walker, Graham C.
Publicado 1999

A model for a umuDC-dependent prokaryotic DNA damage checkpoint

por Opperman, Timothy, Murli, Sumati, Smith, Bradley T., Walker, Graham C.
Publicado 1999

A Role for the umuDC Gene Products of Escherichia coli in Increasing Resistance to DNA Damage in Stationary Phase by Inhibiting the Transition to Exponential Growth

por Murli, Sumati, Opperman, Timothy, Smith, Bradley T., Walker, Graham C.
Publicado 2000

umuDC-dnaQ Interaction and Its Implications for Cell Cycle Regulation and SOS Mutagenesis in Escherichia coli

por Sutton, Mark D., Murli, Sumati, Opperman, Timothy, Klein, Carly, Walker, Graham C.
Publicado 2001

A High-Throughput, Homogeneous, Bioluminescent Assay for Pseudomonas aeruginosa Gyrase Inhibitors and Other DNA Damaging Agents

por Moir, Donald T., Di, Ming, Opperman, Timothy, Schweizer, Herbert P., Bowlin, Terry L.
Publicado 2007

Molecular Mechanism of MBX2319 Inhibition of Escherichia coli AcrB Multidrug Efflux Pump and Comparison with Other Inhibitors

por Vargiu, Attilio V., Ruggerone, Paolo, Opperman, Timothy J., Nguyen, Son T., Nikaido, Hiroshi
Publicado 2014

In Vitro Potency and In Vivo Efficacy of a Novel Bis-Indole Antimicrobial Compound in Reducing Catheter Colonization

por Mansouri, Mohammad D., Opperman, Timothy J., Williams, John D., Stager, Charles, Darouiche, Rabih O.
Publicado 2012

Convallatoxin-Induced Reduction of Methionine Import Effectively Inhibits Human Cytomegalovirus Infection and Replication

por Cohen, Tobias, Williams, John D., Opperman, Timothy J., Sanchez, Roberto, Lurain, Nell S., Tortorella, Domenico
Publicado en J Virol (2016)

Synthesis and antifungal evaluation of head-to-head and head-to-tail bisamidine compounds

por Nguyen, Son T., Kwasny, Steven M., Ding, Xiaoyuan, Williams, John D., Peet, Norton P., Bowlin, Terry L., Opperman, Timothy J.
Publicado en Bioorg Med Chem (2015)

Optimization of a Benzothiazole Indolene Scaffold Targeting Bacterial Cell Wall Assembly

por Chauhan, Jay, Yu, Wenbo, Cardinale, Steven, Opperman, Timothy J, MacKerell, Alexander D, Fletcher, Steven, de Leeuw, Erik PH
Publicado en Drug Des Devel Ther (2020)

Aryl Rhodanines Specifically Inhibit Staphylococcal and Enterococcal Biofilm Formation

por Opperman, Timothy J., Kwasny, Steven M., Williams, John D., Khan, Atiyya R., Peet, Norton P., Moir, Donald T., Bowlin, Terry L.
Publicado 2009

Structure–activity exploration of a small-molecule Lipid II inhibitor

por Fletcher, Steven, Yu, Wenbo, Huang, Jing, Kwasny, Steven M, Chauhan, Jay, Opperman, Timothy J, MacKerell, Alexander D, de Leeuw, Erik PH
Publicado en Drug Des Devel Ther (2015)

Characterization of the Burkholderia thailandensis SOS Response by Using Whole-Transcriptome Shotgun Sequencing

por Ulrich, Ricky L., DeShazer, David, Kenny, Tara A., Ulrich, Melanie P., Moravusova, Anna, Opperman, Timothy, Bavari, Sina, Bowlin, Terry L., Moir, Donald T., Panchal, Rekha G.
Publicado 2013

TAOK3 Phosphorylates the Methylenecyclopropane Nucleoside MBX 2168 to its Monophosphate

por Komazin-Meredith, Gloria, Cardinale, Steven C., Comeau, Katelyn, Magalhaes, Kevin J., Hartline, Caroll B., Williams, John D., Opperman, Timothy J., Prichard, Mark N., Bowlin, Terry L.
Publicado en Antiviral Res (2015)

Lack of AcrB Efflux Function Confers Loss of Virulence on Salmonella enterica Serovar Typhimurium

por Wang-Kan, Xuan, Blair, Jessica M. A., Chirullo, Barbara, Betts, Jonathan, La Ragione, Roberto M., Ivens, Alasdair, Ricci, Vito, Opperman, Timothy J., Piddock, Laura J. V.
Publicado en mBio (2017)

Characterization of a Novel Pyranopyridine Inhibitor of the AcrAB Efflux Pump of Escherichia coli

por Opperman, Timothy J., Kwasny, Steven M., Kim, Hong-Suk, Nguyen, Son T., Houseweart, Chad, D'Souza, Sanjay, Walker, Graham C., Peet, Norton P., Nikaido, Hiroshi, Bowlin, Terry L.
Publicado 2014