Myc regulates aggresome formation, the induction of Noxa, and apoptosis in response to the combination of bortezomib and SAHA

The histone deacetylase inhibitor SAHA enhances cell death stimulated by the proteasome inhibitor bortezomib (BZ) by disrupting BZ-induced aggresome formation. Here we report that Myc regulates the sensitivity of multiple myeloma (MM) cells to BZ + SAHA–induced cell death. In MM cells, Myc expressio...

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Detalhes bibliográficos
Main Authors: Nawrocki, Steffan T., Carew, Jennifer S., Maclean, Kirsteen H., Courage, James F., Huang, Peng, Houghton, Janet A., Cleveland, John L., Giles, Francis J., McConkey, David J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2008
Assuntos:
Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2556625/
https://ncbi.nlm.nih.gov/pubmed/18641367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-12-130823
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