Tipifarnib sensitizes cells to proteasome inhibition by blocking degradation of bortezomib-induced aggresomes

In this report, we investigated the mechanism responsible for synergistic induction of myeloma cell apoptosis induced by the combination of tipifarnib and bortezomib. Immunofluorescence studies revealed that bortezomib alone resulted in an accumulation of puncta of ubiquitinated proteins that was fu...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: David, Ebenezer, Kaufman, Jonathan L., Flowers, Christopher R., Schafer-Hales, Katherine, Torre, Claire, Chen, Jing, Marcus, Adam I., Sun, Shi-Yong, Boise, Lawrence H., Lonial, Sagar
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2010
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4347258/
https://ncbi.nlm.nih.gov/pubmed/20844234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-03-272393
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