Tipifarnib sensitizes cells to proteasome inhibition by blocking degradation of bortezomib-induced aggresomes

In this report, we investigated the mechanism responsible for synergistic induction of myeloma cell apoptosis induced by the combination of tipifarnib and bortezomib. Immunofluorescence studies revealed that bortezomib alone resulted in an accumulation of puncta of ubiquitinated proteins that was fu...

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Pubblicato in:Blood
Autori principali: David, Ebenezer, Kaufman, Jonathan L., Flowers, Christopher R., Schafer-Hales, Katherine, Torre, Claire, Chen, Jing, Marcus, Adam I., Sun, Shi-Yong, Boise, Lawrence H., Lonial, Sagar
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2010
Soggetti:
Lymphoid Neoplasia
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4347258/
https://ncbi.nlm.nih.gov/pubmed/20844234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-03-272393
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