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Proteasome Inhibitor PS-341 (Bortezomib) Induces Calpain-dependent IκBα Degradation
The proteasome, a key component of the ubiquitin-proteasome pathway, has emerged as an important cancer therapeutic target. PS-341 (also called Bortezomib or Velcade) is the first proteasome inhibitor approved for newly diagnosed and relapsed multiple myeloma and is currently being tested in many cl...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2871478/ https://ncbi.nlm.nih.gov/pubmed/20335171 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.072694 |
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