Proteasome Inhibitor PS-341 (Bortezomib) Induces Calpain-dependent IκBα Degradation

The proteasome, a key component of the ubiquitin-proteasome pathway, has emerged as an important cancer therapeutic target. PS-341 (also called Bortezomib or Velcade) is the first proteasome inhibitor approved for newly diagnosed and relapsed multiple myeloma and is currently being tested in many cl...

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Detalhes bibliográficos
Main Authors: Li, Chunyang, Chen, Shuzhen, Yue, Ping, Deng, Xingming, Lonial, Sagar, Khuri, Fadlo R., Sun, Shi-Yong
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2871478/
https://ncbi.nlm.nih.gov/pubmed/20335171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.072694
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