Rictor Undergoes Glycogen Synthase Kinase 3 (GSK3)-dependent, FBXW7-mediated Ubiquitination and Proteasomal Degradation

Rictor, an essential component of mTOR complex 2 (mTORC2), plays a pivotal role in regulating mTOR signaling and other biological functions. Posttranslational regulation of rictor (e.g. via degradation) and its underlying mechanism are largely undefined and thus are the focus of this study. Chemical...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Main Authors: Koo, Junghui, Wu, Xiaoyun, Mao, Zixu, Khuri, Fadlo R., Sun, Shi-Yong
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Signal Transduction
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4447982/
https://ncbi.nlm.nih.gov/pubmed/25897075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.633057
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