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Adenomatous Polyposis Coli (APC) Regulates Multiple Signaling Pathways by Enhancing Glycogen Synthase Kinase-3 (GSK-3) Activity

Glycogen synthase kinase-3 (GSK-3) is essential for many signaling pathways and cellular processes. As Adenomatous Polyposis Coli (APC) functions in many of the same processes, we investigated a role for APC in the regulation of GSK-3-dependent signaling. We find that APC directly enhances GSK-3 act...

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Detalhes bibliográficos
Main Authors: Valvezan, Alexander J., Zhang, Fang, Diehl, J. Alan, Klein, Peter S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3281685/
https://ncbi.nlm.nih.gov/pubmed/22184111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.323337
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