HectD1 E3 Ligase Modifies Adenomatous Polyposis Coli (APC) with Polyubiquitin to Promote the APC-Axin Interaction

The adenomatous polyposis coli (APC) protein functions as a negative regulator of the Wnt signaling pathway. In this capacity, APC forms a “destruction complex” with Axin, CK1α, and GSK3β to foster phosphorylation of the Wnt effector β-catenin earmarking it for Lys-48-linked polyubiquitylation and p...

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Detalhes bibliográficos
Main Authors: Tran, Hoanh, Bustos, Daisy, Yeh, Ronald, Rubinfeld, Bonnee, Lam, Cynthia, Shriver, Stephanie, Zilberleyb, Inna, Lee, Michelle W., Phu, Lilian, Sarkar, Anjali A., Zohn, Irene E., Wertz, Ingrid E., Kirkpatrick, Donald S., Polakis, Paul
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3567630/
https://ncbi.nlm.nih.gov/pubmed/23277359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.415240
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