Tipifarnib sensitizes cells to proteasome inhibition by blocking degradation of bortezomib-induced aggresomes

In this report, we investigated the mechanism responsible for synergistic induction of myeloma cell apoptosis induced by the combination of tipifarnib and bortezomib. Immunofluorescence studies revealed that bortezomib alone resulted in an accumulation of puncta of ubiquitinated proteins that was fu...

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Detaylı Bibliyografya
Yayımlandı:Blood
Asıl Yazarlar: David, Ebenezer, Kaufman, Jonathan L., Flowers, Christopher R., Schafer-Hales, Katherine, Torre, Claire, Chen, Jing, Marcus, Adam I., Sun, Shi-Yong, Boise, Lawrence H., Lonial, Sagar
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society of Hematology 2010
Konular:
Lymphoid Neoplasia
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4347258/
https://ncbi.nlm.nih.gov/pubmed/20844234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-03-272393
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