Aggresome induction by proteasome inhibitor bortezomib and α-tubulin hyperacetylation by tubulin deacetylase (TDAC) inhibitor LBH589 are synergistic in myeloma cells

Histone deacetylase (HDAC) inhibitors have shown cytotoxicity as single agents in preclinical studies for multiple myeloma (MM) cells. LBH589 is a novel hydroxamic acid derivative that at low nanomolar concentrations induces apoptosis in MM cells resistant to conventional therapies via caspase activ...

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Hlavní autoři: Catley, Laurence, Weisberg, Ellen, Kiziltepe, Tanyel, Tai, Yu-Tzu, Hideshima, Teru, Neri, Paola, Tassone, Pierfrancesco, Atadja, Peter, Chauhan, Dharminder, Munshi, Nikhil C., Anderson, Kenneth C.
Médium: Artigo
Jazyk:Inglês
Vydáno: © 2006 by The American Society of Hematology 2006
Témata:
Neoplasia
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895432/
https://ncbi.nlm.nih.gov/pubmed/16728695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-04-016055
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