HDAC Inhibition by LBH589 Affects Phenotype and Function of Human Myeloid Dendritic Cells

LBH589 is a novel pan-HDAC inhibitor which has potent antitumor activity in multiple myeloma and other hematologic malignancies. However, its impact on immune system has not been defined. We here evaluated the effects of LBH589 on human myeloid dendritic cells (DCs) at clinically relevant concentrat...

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Bibliografiske detaljer
Main Authors: Song, W, Tai, Y-T, Tian, Z, Hideshima, T, Chauhan, D, Nanjappa, P, Exley, M A, Anderson, K C, Munshi, N C
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3839585/
https://ncbi.nlm.nih.gov/pubmed/21102427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2010.244
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