The HDAC Inhibitor LBH589 Induces ERK-Dependent Prometaphase Arrest in Prostate Cancer via HDAC6 Inactivation and Down-Regulation

Histone deacetylase inhibitors (HDACIs) have potent anti-cancer activity in a variety of cancer models. Understanding the molecular mechanisms involved in the therapeutic responsiveness of HDACI is needed before its clinical application. This study aimed to determine if a potent HDACI, LBH589 (Panob...

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Bibliografiske detaljer
Main Authors: Chuang, Mei-Jen, Wu, Sheng-Tang, Tang, Shou-Hung, Lai, Xiang-Me, Lai, Hsiao-Chu, Hsu, Kai-Hsiang, Sun, Kuang-Hui, Sun, Guang-Huan, Chang, Sun-Yran, Yu, Dah-Shyong, Hsiao, Pei-Wen, Huang, Shih-Ming, Cha, Tai-Lung
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3762759/
https://ncbi.nlm.nih.gov/pubmed/24023871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0073401
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