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The HDAC inhibitor LBH589 (panobinostat) is an inhibitory modulator of aromatase gene expression
Aromatase converts androgens to estrogens. Although third-generation aromatase inhibitors (AIs) are important drugs in hormonal therapy for breast cancer in postmenopausal women, there are concerns about the side effects associated with the estrogen deprivation achieved with AIs. Expression of aroma...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2890707/ https://ncbi.nlm.nih.gov/pubmed/20534486 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1000917107 |
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