The Histone Deacetylase Inhibitor LBH589 (Panobinostat) Modulates the Crosstalk of Lymphocytes with Hodgkin Lymphoma Cell Lines

Epigenetic changes have been implicated in the malignant phenotype of Hodgkin Reed Sternberg (HRS) cells in Hodgkin lymphoma (HL), where HRS survival and proliferation depends on the microenvironment. The histone-deacetylase (HDAC) inhibitor LBH589 (panobinostat) showed clinical efficacy but its imp...

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Detaylı Bibliyografya
Asıl Yazarlar: Klein, Jan M., Henke, Alexander, Sauer, Maike, Bessler, Martina, Reiners, Katrin S., Engert, Andreas, Hansen, Hinrich P., von Strandmann, Elke Pogge
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2013
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3836980/
https://ncbi.nlm.nih.gov/pubmed/24278143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0079502
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