The Histone Deacetylase Inhibitor LBH589 (Panobinostat) Modulates the Crosstalk of Lymphocytes with Hodgkin Lymphoma Cell Lines

Epigenetic changes have been implicated in the malignant phenotype of Hodgkin Reed Sternberg (HRS) cells in Hodgkin lymphoma (HL), where HRS survival and proliferation depends on the microenvironment. The histone-deacetylase (HDAC) inhibitor LBH589 (panobinostat) showed clinical efficacy but its imp...

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Detalhes bibliográficos
Main Authors: Klein, Jan M., Henke, Alexander, Sauer, Maike, Bessler, Martina, Reiners, Katrin S., Engert, Andreas, Hansen, Hinrich P., von Strandmann, Elke Pogge
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3836980/
https://ncbi.nlm.nih.gov/pubmed/24278143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0079502
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