The Histone Deacetylase Inhibitor LBH589 (Panobinostat) Modulates the Crosstalk of Lymphocytes with Hodgkin Lymphoma Cell Lines

Epigenetic changes have been implicated in the malignant phenotype of Hodgkin Reed Sternberg (HRS) cells in Hodgkin lymphoma (HL), where HRS survival and proliferation depends on the microenvironment. The histone-deacetylase (HDAC) inhibitor LBH589 (panobinostat) showed clinical efficacy but its imp...

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Autors principals: Klein, Jan M., Henke, Alexander, Sauer, Maike, Bessler, Martina, Reiners, Katrin S., Engert, Andreas, Hansen, Hinrich P., von Strandmann, Elke Pogge
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2013
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3836980/
https://ncbi.nlm.nih.gov/pubmed/24278143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0079502
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