THE ANTI-MELANOMA ACTIVITY OF THE HISTONE DEACETYLASE INHIBITOR PANOBINOSTAT (LBH589) IS MEDIATED BY DIRECT TUMOR CYTOTOXICITY AND INCREASED TUMOR IMMUNOGENICITY

OBJECTIVES: Melanoma is the deadliest skin cancer, and its incidence has been increasing faster than any other cancer. Although immunogenic, melanoma is not effectively cleared by host immunity. In this study, we investigate the therapeutic, anti-melanoma potential of the histone deacetylase inhibit...

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Auteurs principaux: Woods, David M., Woan, Karrune, Cheng, Fengdong, Wang, Hongwei, Perez-Villarroel, Patricio, Lee, Calvin, Lienlaf, Maritza, Atadja, Peter, Seto, Edward, Weber, Jeffrey, Sotomayor, Eduardo M., Villagra, Alejandro
Format: Artigo
Langue:Inglês
Publié: 2013
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4012016/
https://ncbi.nlm.nih.gov/pubmed/23963286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CMR.0b013e328364c0ed
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