Molecular Mechanism of the Cell Death Induced by the Histone Deacetylase Pan Inhibitor LBH589 (Panobinostat) in Wilms Tumor Cells

BACKGROUND: Wilms tumor (WT) is an embryonic kidney cancer, for which histone acetylation might be a therapeutic target. LBH589, a novel targeted agent, suppresses histone deacetylases in many tumors. This study investigated the antitumor activity of LBH589 in SK-NEP-1 and G401 cells. METHODS: SK-NE...

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Publicado no:PLoS One
Main Authors: Yan-Fang, Tao, Zhi-Heng, Li, Li-Xiao, Xu, Fang, Fang, Jun, Lu, Gang, Li, Lan, Cao, Na-Na, Wang, Xiao-Juan, Du, Li-Chao, Sun, Wen-Li, Zhao, Pei-Fang, Xiao, He, Zhao, Guang-Hao, Su, Yan-Hong, Li, Yi-Ping, Li, Yun-Yun, Xu, Hui-Ting, Zhou, Yi, Wu, Mei-Fang, Jin, Lin, Liu, Jian, Ni, Shao-Yan, Hu, Xue-Ming, Zhu, Xing, Feng, Jian, Wang, Jian, Pan
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4503685/
https://ncbi.nlm.nih.gov/pubmed/26176219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0126566
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