Aggresome induction by proteasome inhibitor bortezomib and α-tubulin hyperacetylation by tubulin deacetylase (TDAC) inhibitor LBH589 are synergistic in myeloma cells

Histone deacetylase (HDAC) inhibitors have shown cytotoxicity as single agents in preclinical studies for multiple myeloma (MM) cells. LBH589 is a novel hydroxamic acid derivative that at low nanomolar concentrations induces apoptosis in MM cells resistant to conventional therapies via caspase activ...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Catley, Laurence, Weisberg, Ellen, Kiziltepe, Tanyel, Tai, Yu-Tzu, Hideshima, Teru, Neri, Paola, Tassone, Pierfrancesco, Atadja, Peter, Chauhan, Dharminder, Munshi, Nikhil C., Anderson, Kenneth C.
Format: Artigo
Sprog:Inglês
Udgivet: © 2006 by The American Society of Hematology 2006
Fag:
Neoplasia
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895432/
https://ncbi.nlm.nih.gov/pubmed/16728695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-04-016055
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker