Aggresome induction by proteasome inhibitor bortezomib and α-tubulin hyperacetylation by tubulin deacetylase (TDAC) inhibitor LBH589 are synergistic in myeloma cells

Histone deacetylase (HDAC) inhibitors have shown cytotoxicity as single agents in preclinical studies for multiple myeloma (MM) cells. LBH589 is a novel hydroxamic acid derivative that at low nanomolar concentrations induces apoptosis in MM cells resistant to conventional therapies via caspase activ...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Catley, Laurence, Weisberg, Ellen, Kiziltepe, Tanyel, Tai, Yu-Tzu, Hideshima, Teru, Neri, Paola, Tassone, Pierfrancesco, Atadja, Peter, Chauhan, Dharminder, Munshi, Nikhil C., Anderson, Kenneth C.
Formato: Artigo
Idioma:Inglês
Publicado em: © 2006 by The American Society of Hematology 2006
Assuntos:
Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895432/
https://ncbi.nlm.nih.gov/pubmed/16728695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-04-016055
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados