Panobinostat (LBH589)-induced acetylation of tubulin impairs megakaryocyte maturation and platelet formation

Drug-induced thrombocytopenia often results from dysregulation of normal megakaryocytopoiesis. In this study, we investigated the mechanisms responsible for thrombocytopenia associated with the use of Panobinostat (LBH589), a histone deacetylase inhibitor (HDACi) with promising anti-cancer activitie...

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Bibliographic Details
Main Authors: Iancu-Rubin, Camelia, Gajzer, David, Mosoyan, Goar, Feller, Faye, Mascarenhas, John, Hoffman, Ronald
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3381910/
https://ncbi.nlm.nih.gov/pubmed/22381681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exphem.2012.02.004
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