A phase I trial of panobinostat (LBH589) in patients with metastatic melanoma

Epigenetic alterations by histone/protein deacetylases (HDACs) are one of the many mechanisms that cancer cells use to alter gene expression and promote growth. HDAC inhibitors have proven to be effective in the treatment of specific malignancies, particularly in combination with other anticancer ag...

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Vydáno v:Cancer Med
Hlavní autoři: Ibrahim, Nageatte, Buchbinder, Elizabeth I., Granter, Scott R., Rodig, Scott J., Giobbie‐Hurder, Anita, Becerra, Carla, Tsiaras, Argyro, Gjini, Evisa, Fisher, David E., Hodi, F. Stephen
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2016
Témata:
Clinical Cancer Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5119958/
https://ncbi.nlm.nih.gov/pubmed/27748045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cam4.862
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