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Phase I study of panobinostat (LBH589) and letrozole in post-menopausal metastatic breast cancer patients
INTRODUCTION/BACKGROUND: Histone deacetylase inhibitors have been found to restore sensitivity to the estrogen receptor in endocrine resistant and triple negative breast cancer cell lines. We decided to test panobinostat, a pan histone deacetylase inhibitor, based on preclinical data in combination...
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| Publicado no: | Clin Breast Cancer |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5567753/ https://ncbi.nlm.nih.gov/pubmed/26774555 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.clbc.2015.11.003 |
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