Phase I study of panobinostat (LBH589) and letrozole in post-menopausal metastatic breast cancer patients

INTRODUCTION/BACKGROUND: Histone deacetylase inhibitors have been found to restore sensitivity to the estrogen receptor in endocrine resistant and triple negative breast cancer cell lines. We decided to test panobinostat, a pan histone deacetylase inhibitor, based on preclinical data in combination...

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Vydáno v:Clin Breast Cancer
Hlavní autoři: Tan, Winston W., Allred, Jacob B., Moreno-Aspitia, Alvaro, Northfelt, Donald W., Ingle, James N., Goetz, Matthew P., Perez, Edith A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5567753/
https://ncbi.nlm.nih.gov/pubmed/26774555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.clbc.2015.11.003
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