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Making insulin-deficient type 1 diabetic rodents thrive without insulin
Terminally ill insulin-deficient rodents with uncontrolled diabetes due to autoimmune or chemical destruction of β-cells were made hyperleptinemic by adenoviral transfer of the leptin gene. Within ≈10 days their severe hyperglycemia and ketosis were corrected. Despite the lack of insulin, moribund a...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
National Academy of Sciences
2008
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2544580/ https://ncbi.nlm.nih.gov/pubmed/18779578 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0806993105 |
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